| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2020-08-21 |
| タイトル |
|
|
タイトル |
Prognostic impact of the mean platelet volume/platelet count ratio in terms of survival in advanced non-small cell lung cancer. |
| タイトル |
|
|
タイトル |
Prognostic impact of the mean platelet volume/platelet count ratio in terms of survival in advanced non-small cell lung cancer. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Adult |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Aged |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Aged, 80 and over |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Blood Platelets |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Carcinogenesis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Carcinoma, Non-Small-Cell Lung |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Cell Count |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Female |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Humans |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Lung Neoplasms |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Male |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Mean Platelet Volume |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Middle Aged |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Neoplasm Staging |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Prognosis |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_46ec |
|
資源タイプ |
thesis |
| 別タイトル |
|
|
その他のタイトル |
（進行非小細胞肺癌の生存期間における血小板容積指数の予後への影響 ） |
| 著者 |
片芝, 詔子
Inagaki, Noriko
Kibata, Kayoko
Tamaki, Takeshi
Shimizu, Toshiki
Nomura, Shosaku
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Mean platelet volume (MPV) is a platelet volume index. Classically, MPV was recognized as a hallmark of platelet activation. Recent studies have revealed that the MPV and MPV/platelet count (PC) ratio can predict long-term mortality in patients with ischemic cardio-vascular disease. In addition, these indices were correlated with the pathophysiological characteristics of patients with various disorders, including malignant tumors. |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
We retrospectively analyzed various hematological indices of patients with advanced non-small cell lung cancer (NSCLC). The aim of this study was to evaluate the contribution of platelet volume indices to survival in these patients. |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
A total of 268 patients were enrolled in the study. The median age of the patients was 68 years (range: 31-87 years). We compared various hematological indices between the NSCLC group and an age- and sex-matched comparator group. MPV was significantly decreased in the NSCLC group compared to the comparator group. In contrast, the PC was significantly increased in the NSCLC group. Consequently, the MPV/PC ratio was also decreased in the NSCLC group (0.397 vs. 0.501). In receiver operating characteristics (ROC) curve analysis, the MPV/PC ratio was associated with a sensitivity of 62.3% and a specificity of 74.6% at a cutoff value of 0.408730 (area under the curve [AUC], 0.72492)]. Univariate analysis revealed that overall survival (OS) was significantly shorter in the group with a low MPV/PC ratio than in the other group (median survival time [MST]: 10.3 months vs. 14.5 months, log-rank, P=0.0245). Multivariate analysis confirmed that a low MPV/PC ratio was an independent unfavorable predictive factor for OS (hazard ratio [HR]: 1.668, 95% confidence interval [CI]: 1.235-2.271, P=0.0008). |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
These data clearly demonstrate that the MPV/PC ratio was closely associated with survival in patients with advanced NSCLC. |
| 学位名 |
|
|
学位名 |
博士（医学） |
| 学位授与機関 |
|
|
|
学位授与機関名 |
関西医科大学 |
| 学位授与年度 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
令和元年度 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2019-09-24 |
| 学位授与番号 |
|
|
学位授与番号 |
課博第1042号 |
| 書誌情報 |
Lung cancer
en : Lung cancer
巻 83,
号 1,
p. 97-101,
発行日 2014-01
|
| DOI |
|
|
|
10.1016/j.lungcan.2013.08.020 |
|
|
https://doi.org/10.1016/j.lungcan.2013.08.020 |
論文要旨（要約） (292.5 kB)
