{"created":"2023-05-15T08:16:15.304860+00:00","id":93,"links":{},"metadata":{"_buckets":{"deposit":"d7f60859-243a-43df-a6b0-a33351bbe0ec"},"_deposit":{"created_by":6,"id":"93","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"93"},"status":"published"},"_oai":{"id":"oai:kmu.repo.nii.ac.jp:00000093","sets":["2:13:15:16"]},"author_link":["586","587","582","585","584","583"],"item_10006_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"（進行非小細胞肺癌の生存期間における血小板容積指数の予後への影響 ）"}]},"item_10006_biblio_info_23":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"101","bibliographicPageStart":"97","bibliographicVolumeNumber":"83","bibliographic_titles":[{"bibliographic_title":"Lung cancer"},{"bibliographic_title":"Lung cancer","bibliographic_titleLang":"en"}]}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2019-09-24"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"関西医科大学"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"令和元年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Mean platelet volume (MPV) is a platelet volume index. Classically, MPV was recognized as a hallmark of platelet activation. Recent studies have revealed that the MPV and MPV/platelet count (PC) ratio can predict long-term mortality in patients with ischemic cardio-vascular disease. In addition, these indices were correlated with the pathophysiological characteristics of patients with various disorders, including malignant tumors.","subitem_description_type":"Abstract"},{"subitem_description":"We retrospectively analyzed various hematological indices of patients with advanced non-small cell lung cancer (NSCLC). The aim of this study was to evaluate the contribution of platelet volume indices to survival in these patients.","subitem_description_type":"Abstract"},{"subitem_description":"A total of 268 patients were enrolled in the study. The median age of the patients was 68 years (range: 31-87 years). We compared various hematological indices between the NSCLC group and an age- and sex-matched comparator group. MPV was significantly decreased in the NSCLC group compared to the comparator group. In contrast, the PC was significantly increased in the NSCLC group. Consequently, the MPV/PC ratio was also decreased in the NSCLC group (0.397 vs. 0.501). In receiver operating characteristics (ROC) curve analysis, the MPV/PC ratio was associated with a sensitivity of 62.3% and a specificity of 74.6% at a cutoff value of 0.408730 (area under the curve [AUC], 0.72492)]. Univariate analysis revealed that overall survival (OS) was significantly shorter in the group with a low MPV/PC ratio than in the other group (median survival time [MST]: 10.3 months vs. 14.5 months, log-rank, P=0.0245). Multivariate analysis confirmed that a low MPV/PC ratio was an independent unfavorable predictive factor for OS (hazard ratio [HR]: 1.668, 95% confidence interval [CI]: 1.235-2.271, P=0.0008).","subitem_description_type":"Abstract"},{"subitem_description":"These data clearly demonstrate that the MPV/PC ratio was closely associated with survival in patients with advanced NSCLC.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"課博第1042号"}]},"item_10006_link_22":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_link_text":"10.1016/j.lungcan.2013.08.020","subitem_link_url":"https://doi.org/10.1016/j.lungcan.2013.08.020"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"片芝, 詔子"},{"creatorName":"カタシバ, ノリコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"582","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inagaki, Noriko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"583","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kibata, Kayoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"584","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tamaki, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"585","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimizu, Toshiki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"586","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nomura, Shosaku","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"587","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-21"}],"displaytype":"simple","filename":"甲1042　論文要旨（要約）.pdf","filesize":[{"value":"292.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"論文要旨（要約）","url":"https://kmu.repo.nii.ac.jp/record/93/files/甲1042　論文要旨（要約）.pdf"},"version_id":"e2e8382d-c810-4e5a-8cf3-24514e8ac1f9"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-21"}],"displaytype":"simple","filename":"甲1042　審査結果要旨.pdf","filesize":[{"value":"124.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査結果要旨","url":"https://kmu.repo.nii.ac.jp/record/93/files/甲1042　審査結果要旨.pdf"},"version_id":"5a3cbbb2-36d3-41c4-be61-68701983cf09"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-01-13"}],"displaytype":"simple","filename":"甲1042 片芝詔子Ｄｒ主論文.pdf","filesize":[{"value":"538.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"主論文全文","url":"https://kmu.repo.nii.ac.jp/record/93/files/甲1042 片芝詔子Ｄｒ主論文.pdf"},"version_id":"1e462f9d-f656-4429-807c-a9c45e292267"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adult","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Aged","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Aged, 80 and over","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Blood Platelets","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Carcinogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Carcinoma, Non-Small-Cell Lung","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell Count","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Female","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lung Neoplasms","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Male","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mean Platelet Volume","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Middle Aged","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Neoplasm Staging","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Prognosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Prognostic impact of the mean platelet volume/platelet count ratio in terms of survival in advanced non-small cell lung cancer.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prognostic impact of the mean platelet volume/platelet count ratio in terms of survival in advanced non-small cell lung cancer."},{"subitem_title":"Prognostic impact of the mean platelet volume/platelet count ratio in terms of survival in advanced non-small cell lung cancer.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"6","path":["16"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-08-21"},"publish_date":"2020-08-21","publish_status":"0","recid":"93","relation_version_is_last":true,"title":["Prognostic impact of the mean platelet volume/platelet count ratio in terms of survival in advanced non-small cell lung cancer."],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T08:21:08.048719+00:00"}