| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2021-10-15 |
| タイトル |
|
|
タイトル |
Histopathological analysis of retrieved thrombi from patients with acute ischemic stroke with malignant tumors. |
| タイトル |
|
|
タイトル |
Histopathological analysis of retrieved thrombi from patients with acute ischemic stroke with malignant tumors. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_46ec |
|
資源タイプ |
thesis |
| 別タイトル |
|
|
その他のタイトル |
急性脳主幹動脈閉塞をきたした担癌患者における回収血栓の組織学的検討 |
| 著者 |
片岡, 優子
Kataoka, Yuko
Sonoda, Kazutaka
Takahashi, Jun C
Ishibashi-Ueda, Hatsue
Toyoda, Kazunori
Yakushiji, Yusuke
Kusaka, Hirofumi
Koga, Masatoshi
|
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
The procoagulant state in cancer increases the thrombotic risk, and underlying cancer could affect treatment strategies and outcomes in patients with ischemic stroke. However, the histopathological characteristics of retrieved thrombi in patients with cancer have not been well studied. This study aimed to assess the histopathological difference between thrombi in patients with and without cancer. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
We studied consecutive patients with acute major cerebral artery occlusion who were treated with endovascular therapy between October 2010 and December 2016 in our single-center registry. The retrieved thrombi were histopathologically investigated with hematoxylin and eosin and Masson's trichrome staining. The organization and proportions of erythrocyte and fibrin/platelet components were studied using a lattice composed of 10×10 squares. |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Of the 180 patients studied, 17 (8 women, age 76.5±11.5 years) had cancer and 163 (69 women, age 74.1±11.2 years) did not. Those with cancer had a higher proportion of fibrin/platelets (56.6±27.4% vs 40.1±23.9%, p=0.008), a smaller proportion of erythrocytes (42.1±28.3% vs 57.5±25.1%, p=0.019), and higher serum D-dimer levels (5.9±8.2 vs 2.4±4.3 mg/dL, p=0.005) compared with the non-cancer cases. Receiver operating characteristic curve analysis showed the cut-off ratio of fibrin/platelet components related to cancer was 55.7% with a sensitivity of 74.8%, specificity 58.8% and area under the curve (AUC) value of 0.67 (95% CI 0.53 to 0.81), and the cut-off ratio of erythrocyte components was 44.7% with a sensitivity of 71.2%, specificity 58.9% and AUC value of 0.66 (95% CI 0.51 to 0.80). |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Thromboemboli of major cerebral arteries in patients with cancer were mainly composed of fibrin/platelet-rich components. |
| 学位名 |
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|
学位名 |
博士（医学） |
| 学位授与機関 |
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学位授与機関名 |
関西医科大学 |
| 学位授与年度 |
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内容記述タイプ |
Other |
|
内容記述 |
令和3年度 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2021-09-15 |
| 書誌情報 |
Journal of neurointerventional surgery
en : Journal of neurointerventional surgery
発行日 2021-05-28
|
| DOI |
|
|
|
10.1136/neurintsurg-2020-017195 |
|
|
https://pubmed.ncbi.nlm.nih.gov/34050032/#:~:text=DOI%3A-,10.1136/neurintsurg-2020-017195,-Abstract |
| 他の資源との関係 |
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関連名称 |
課博第1109号 |
論文要旨（要約） (193.9 kB)
