| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2020-11-25 |
| タイトル |
|
|
タイトル |
Role of phosphorylated Smad3 signal components in intraductal papillary mucinous neoplasm of pancreas. |
| タイトル |
|
|
タイトル |
Role of phosphorylated Smad3 signal components in intraductal papillary mucinous neoplasm of pancreas. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_46ec |
|
資源タイプ |
thesis |
| 別タイトル |
|
|
その他のタイトル |
（膵管内乳頭粘液性腫瘍におけるリン酸化 Smad3シグナルの解析） |
| 著者 |
堀, 雄一
Hori, Yuichi
Ikeura, Tsukasa
Yamaguchi, Takashi
Yoshida, Katsunori
Matsuzaki, Koichi
Ishida, Mitsuaki
Satoi, Sohei
Okazaki, Kazuichi
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Malignant intraductal papillary mucinous neoplasm (IPMN) has poor prognosis. The carcinogenesis of IPMN is not clear. The aim of this study was to clarify transitions in phosphorylated Smad3 signaling during IPMN carcinogenesis. |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
By using immunohistochemistry, we examined the expression of pSmad3C and pSmad3L from 51 IPMN surgical specimens resected at our institution between 2010 and 2013. We also examined the expression of Ki-67, c-Myc and p-JNK. |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
The median immunostaining index of pSmad3C was 79.2% in low-grade dysplasia, 74.9% in high-grade dysplasia, and 42.0% in invasive carcinoma (P <0.01), whereas that of pSmad3L was 3.4%, 4.3%, and 42.4%, respectively (P <0.01). There was a negative relationship between the expression of pSmad3C and c-Myc (P<0.001, r = -0.615) and a positive relationship between the expression of pSmad3L and c-Myc (P<0.001, r = 0.696). Negative relationship between the expression of pSmad3C and Ki-67 (P<0.01, r = -0.610) and positive relationship between the expression of pSmad3L and Ki-67 (P<0.01, r = 0.731) were confirmed. p-JNK-positive cells were frequently observed among pSmad3L-positive cancer cells. The median of pSmad3L/pSmad3C ratio in the non-recurrence group and the recurrence group were 0.58 (range, 0.05-0.93), 3.83 (range, 0.85-5.96), respectively (P = 0.02). The median immunostaining index of c-Myc in the non-recurrence group and the recurrence group were 2.91 (range, 0-36.9) and 82.1 (range, 46.2-97.1), respectively (P = 0.02). The median immunostaining index of Ki-67 in the non-recurrence group and the recurrence group were 12.9 (range 5.69-30.8) and 90.9 (range 52.9-98.5), respectively (P = 0.02). |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
pSmad3L was upregulated in malignant IPMN. pSmad3L/pSmad3C ratio may be a useful prognostic factor in IPMN. |
| 学位名 |
|
|
学位名 |
博士（医学） |
| 学位授与機関 |
|
|
|
学位授与機関名 |
関西医科大学 |
| 学位授与年度 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
令和2年度 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2020-09-29 |
| 学位授与番号 |
|
|
学位授与番号 |
課博第1070号 |
| 書誌情報 |
Hepatobiliary & pancreatic diseases international : HBPD INT
en : Hepatobiliary & pancreatic diseases international : HBPD INT
発行日 2020-06-02
|
| DOI |
|
|
|
10.1016/j.hbpd.2020.05.007 |
|
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https://doi.org/10.1016/j.hbpd.2020.05.007 |
論文要旨（要約） (166.4 kB)
