| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2020-08-26 |
| タイトル |
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|
タイトル |
Impaired peripheral nerve regeneration in type-2 diabetic mouse model |
| タイトル |
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タイトル |
Impaired peripheral nerve regeneration in type-2 diabetic mouse model |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_46ec |
|
資源タイプ |
thesis |
| 別タイトル |
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その他のタイトル |
２型糖尿病マウスにおける末梢神経再生の遅延 |
| 著者 |
PHAM MINH VUONG
Pham, Vuong M.
Tu, Nguyen Huu
Katano, Tayo
Matsumura, Shinji
Saito, Akira
Yamada, Akihiro
Furue, Hidemasa
Ito, Seiji
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Peripheral neuropathy is one of the most common and serious complications of type-2 diabetes. Diabetic neuropathy is characterized by a distal symmetrical sensorimotor polyneuropathy, and its incidence increases in patients 40 years of age or older. In spite of extensive research over decades, there are few effective treatments for diabetic neuropathy besides glucose control and improved lifestyle. The earliest changes in diabetic neuropathy occur in sensory nerve fibers, with initial degeneration and regeneration resulting in pain. To seek its effective treatment, here we prepared a type-2 diabetic mouse model by giving mice 2 injections of streptozotocin and nicotinamide and examining the ability for nerve regeneration by using a sciatic nerve transection-regeneration model previously established by us. Seventeen weeks after the last injection, the mice exhibited symptoms of type-2 diabetes, that is, impaired glucose tolerance, decreased insulin level, mechanical hyperalgesia, and impaired sensory nerve fibers in the plantar skin. These mice showed delayed functional recovery and nerve regeneration by 2 weeks compared with young healthy mice and by 1 week compared with age-matched non-diabetic mice after axotomy. Furthermore, type-2 diabetic mice displayed increased expression of PTEN in their DRG neurons. Administration of a PTEN inhibitor at the cutting site of the nerve for 4 weeks promoted the axonal transport and functional recovery remarkably. This study demonstrates that peripheral nerve regeneration was impaired in type-2 diabetic model and that its combination with sciatic nerve transection is suitable for the study of the pathogenesis and treatment of early diabetic neuropathy. |
| 学位名 |
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学位名 |
博士(医学) |
| 学位授与機関 |
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学位授与機関名 |
関西医科大学 |
| 学位授与年度 |
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内容記述タイプ |
Other |
|
内容記述 |
平成29年度 |
| 学位授与年月日 |
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学位授与年月日 |
2018-03-27 |
| 学位授与番号 |
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|
学位授与番号 |
課博第1022号 |
| 書誌情報 |
European Journal of Neuroscience
en : European Journal of Neuroscience
巻 47,
号 2,
p. 126-139,
発行日 2018
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| DOI |
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10.1111/ejn.13771 |
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https://doi.org/10.1111/ejn.13771 |
論文要旨（要約） (271.2 kB)
