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Cells Expressing Prominin-1 in Neonatal Murine Inferior Colliculus Differentiate into Neurons and Glia
https://kmu.repo.nii.ac.jp/records/134
https://kmu.repo.nii.ac.jp/records/134332da7ee-ed61-4d82-9b55-7490c0148b5f
| 名前 / ファイル | ライセンス | アクション |
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論文要旨（要約） (154.9 kB)
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審査結果要旨 (76.0 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2020-08-26 | |||||
| タイトル | ||||||
| タイトル | Cells Expressing Prominin-1 in Neonatal Murine Inferior Colliculus Differentiate into Neurons and Glia | |||||
| タイトル | ||||||
| タイトル | Cells Expressing Prominin-1 in Neonatal Murine Inferior Colliculus Differentiate into Neurons and Glia | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
| 資源タイプ | thesis | |||||
| 別タイトル | ||||||
| その他のタイトル | 新生仔マウス下丘Prominin-1陽性細胞は神経細胞やグリア細胞に分化する | |||||
| 著者 |
岡崎, はるか
× 岡崎, はるか× Okazaki, Haruka× Kanda, Akira× Kanda, Seiji× Shimono, Takaki× Yun, Yasutaka× Kobayashi, Yoshiki× Wang, Zeyun× Ooka, Hisashi× Suzuki, Kensuke× Van, Dan Bui× Tomoda, Koichi× Iwai, Hiroshi× Nishiyama, Toshimasa |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Inferior colliculus (IC) is a major center for the integration and processing of acoustic information from ascending auditory pathways. Damage to the IC as well as normal aging can impair auditory function. Novel strategies such as stem cell (SC)-based regenerative therapy are required for functional recovery because mature neural cells have a minimal regenerative capacity after an injury. However, it is not known if there are neural stem cells (NSCs) in the IC. Herein, we screened for NSCs by surface marker analysis using flow cytometry. Isolated IC cells expressing prominin-1 (CD133) exhibited the cardinal NSC properties self-renewal capacity, expression of known NSC markers (SOX2 and nestin), and multipotency. Prominin-1-expressing cells from neonatal IC generated neurospheres, and culture of these neurospheres in differentiation-conditioned medium gave rise to gamma-aminobutyric acid-ergic (GABAergic) neurons, astrocytes, and oligodendrocytes. The presence of NSC-like cells in the IC has important implications for understanding IC development and for potential regenerative therapy. | |||||
| 学位名 | ||||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 関西医科大学 | |||||
| 学位授与年度 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成29年度 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2018-03-27 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 課博第1013号 | |||||
| 書誌情報 |
Molecular Neurobiology en : Molecular Neurobiology 巻 55, 号 6, p. 4998-5005, 発行日 2017 |
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