| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2020-08-25 |
| タイトル |
|
|
タイトル |
Heparin Induces the Mobilization of Heart-Derived Multipotent Mesoangioblasts During Cardiac Surgery With Cardiopulmonary Bypass or Cardiac Catheterization. |
| タイトル |
|
|
タイトル |
Heparin Induces the Mobilization of Heart-Derived Multipotent Mesoangioblasts During Cardiac Surgery With Cardiopulmonary Bypass or Cardiac Catheterization. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Aged |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Aged, 80 and over |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Cardiac Catheterization |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Cardiopulmonary Bypass |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Female |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Heart Atria |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Heparin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Hepatocyte Growth Factor |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Humans |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Male |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Mesenchymal Stem Cells |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Middle Aged |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_46ec |
|
資源タイプ |
thesis |
| 別タイトル |
|
|
その他のタイトル |
(ヘパリンは心臓カテーテル検査中、人工心肺を用いた心臓手術中に心臓由来のヒト多能性mesoangioblastsを循環血中に動員する) |
| 著者 |
秦, 亮嘉
Hata, Yoshihiro
Iwasaki, Masayoshi
Fujitaka, Keisuke
Park, Haengnam
Sato, Daisuke
Enoki, Chiharu
Minato, Naoki
Horitani, Keita
Nakano, Miyuki
Kishimoto, Hiroshi
Wada, Kensaku
Koyanagi, Masamichi
Adachi, Yasushi
Yamamoto, Yoshihiro
Zeiher, Andreas M
Dimmeler, Stefanie
Shiojima, Ichiro
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
We previously identified circulating mesoangioblasts (cMABs), a subset of mesenchymal stem cells that express cardiac mesodermal markers, in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). We also found that hepatocyte growth factor (HGF) is upregulated during cardiac surgery with CPB in humans, and induces MAB-like cell mobilization in rodents. These results strongly suggest that heparin induced MAB mobilization via HGF upregulation. Here, we tested this hypothesis in patients undergoing cardiac surgery or cardiac catheterization. We also examined whether human cMABs are derived from the heart.Methods and Results:Plasma HGF levels were determined by ELISA. Mononuclear cells isolated from blood samples were cultured on fibronectin-coated dishes, and outgrowing cMAB colonies were counted. We first confirmed that HGF upregulation and cMAB mobilization were observed before the start of CPB, excluding the possibility that CPB is the primary inducer of cMAB mobilization. We then examined patients undergoing cardiac catheterization and found that heparin significantly increased plasma HGF levels and the number of cMAB colonies in a dose-dependent manner. The results of simultaneous blood sampling from the aortic sinus, coronary sinus, and right atrium were consistent with the notion that human cMABs are derived from the heart. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Human cMABs are mobilized by heparin injection during cardiac surgery or cardiac catheterization, presumably via HGF upregulation. |
| 学位名 |
|
|
学位名 |
博士（医学） |
| 学位授与機関 |
|
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|
学位授与機関名 |
関西医科大学 |
| 学位授与年度 |
|
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内容記述タイプ |
Other |
|
内容記述 |
平成29年度 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2018-03-27 |
| 学位授与番号 |
|
|
学位授与番号 |
論博第721号 |
| 書誌情報 |
Circulation journal : official journal of the Japanese Circulation Society
en : Circulation journal : official journal of the Japanese Circulation Society
巻 82,
号 5,
p. 1459-1465,
発行日 2018
|
| DOI |
|
|
|
10.1253/circj.CJ-17-0324 |
|
|
https://doi.org/10.1253/circj.cj-17-0324 |
論文要旨（要約） (185.7 kB)
