{"created":"2023-05-15T08:16:15.510296+00:00","id":96,"links":{},"metadata":{"_buckets":{"deposit":"85f89fef-3672-452a-ae2e-ed605ec68aec"},"_deposit":{"created_by":6,"id":"96","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"96"},"status":"published"},"_oai":{"id":"oai:kmu.repo.nii.ac.jp:00000096","sets":["2:13:18:20"]},"author_link":["608","619","612","610","611","613","618","617","615","609","605","620","622","607","621","614","623","616","624","606"],"item_10006_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"（手掌および足底の上皮における幹細胞による汗腺の組織維持）"}]},"item_10006_biblio_info_23":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-10-23","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"338","bibliographicPageStart":"333","bibliographicVolumeNumber":"466","bibliographic_titles":[{"bibliographic_title":"Biochemical and biophysical research communications"},{"bibliographic_title":"Biochemical and biophysical research communications","bibliographic_titleLang":"en"}]}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2019-03-26"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"関西医科大学"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"平成30年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The skin is responsible for a variety of physiological functions and is critical for wound healing and repair. Therefore, the regenerative capacity of the skin is important. However, stem cells responsible for maintaining the acral epithelium had not previously been identified. In this study, we identified the specific stem cells in the acral epithelium that participate in the long-term maintenance of sweat glands, ducts, and interadnexal epidermis and that facilitate the regeneration of these structures following injury. Lgr6-positive cells and Bmi1-positive cells were found to function as long-term multipotent stem cells that maintained the entire eccrine unit and the interadnexal epidermis. However, while Lgr6-positive cells were rapidly cycled and constantly supplied differentiated cells, Bmi1-positive cells were slow to cycle and occasionally entered the cell cycle under physiological conditions. Upon irradiation-induced injury, Bmi1-positive cells rapidly proliferated and regenerated injured epithelial tissue. Therefore, Bmi1-positive stem cells served as reservoir stem cells. Lgr5-positive cells were rapidly cycled and maintained only sweat glands; therefore, we concluded that these cells functioned as lineage-restricted progenitors. Taken together, our data demonstrated the identification of stem cells that maintained the entire acral epithelium and supported the different roles of three cellular classes. ","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"論博第730号"}]},"item_10006_link_22":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_link_text":"10.1016/j.bbrc.2015.09.022","subitem_link_url":"https://doi.org/10.1016/j.bbrc.2015.09.022"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大江, 秀一"},{"creatorName":"オオエ, シュウイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"605","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohe, Shuichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"606","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Toshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"607","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yanai, Hirotsugu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"608","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Komai, Yoshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"609","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Omachi, Taichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"610","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanno, Shohei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"611","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kiyomichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"612","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishigaki, Kazuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"613","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saiga, Kazuho","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"614","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Naohiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"615","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohsugi, Haruyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tokuyama, Yoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"617","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Atsumi, Naho","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"618","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hisha, Hiroko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"619","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Naoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kumano, Keiki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamazaki, Fumikazu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"622","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okamoto, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"623","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ueno, Hiroo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"624","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-21"}],"displaytype":"simple","filename":"乙730　論文要旨（要約）.pdf","filesize":[{"value":"167.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"論文要旨（要約）","url":"https://kmu.repo.nii.ac.jp/record/96/files/乙730　論文要旨（要約）.pdf"},"version_id":"90ae9dc0-8358-41ab-a4e7-4c41cd597049"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-21"}],"displaytype":"simple","filename":"乙730　審査結果要旨.pdf","filesize":[{"value":"116.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査結果要旨","url":"https://kmu.repo.nii.ac.jp/record/96/files/乙730　審査結果要旨.pdf"},"version_id":"4ffcbaa5-e4be-45a0-9a3e-902639de3191"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Animals","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Body Weight","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell Lineage","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell Proliferation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Epidermis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Epithelium","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Female","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Gene Expression Regulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Imaging, Three-Dimensional","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Male","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mice, Inbred C57BL","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mice, Transgenic","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Multipotent Stem Cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Polycomb Repressive Complex 1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Proto-Oncogene Proteins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Receptors, G-Protein-Coupled","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Skin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Stem Cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sweat Glands","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Maintenance of sweat glands by stem cells located in the acral epithelium.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Maintenance of sweat glands by stem cells located in the acral epithelium."},{"subitem_title":"Maintenance of sweat glands by stem cells located in the acral epithelium.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"6","path":["20"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-08-21"},"publish_date":"2020-08-21","publish_status":"0","recid":"96","relation_version_is_last":true,"title":["Maintenance of sweat glands by stem cells located in the acral epithelium."],"weko_creator_id":"6","weko_shared_id":6},"updated":"2023-05-15T08:28:59.614755+00:00"}