| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2020-08-19 |
| タイトル |
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|
タイトル |
Increased CD69 expression on activated eosinophils in eosinophilic chronic rhinosinusitis correlates with clinical findings. |
| タイトル |
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|
タイトル |
Increased CD69 expression on activated eosinophils in eosinophilic chronic rhinosinusitis correlates with clinical findings. |
|
言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_46ec |
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資源タイプ |
thesis |
| 別タイトル |
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その他のタイトル |
（ 好酸球性副鼻腔炎における活性化好酸球の CD69 分子 の発現量の増加は 臨床所見と相関する) |
| 著者 |
尹, 泰貴
Yun, Yasutaka
Kanda, Akira
Kobayashi, Yoshiki
Van Bui, Dan
Suzuki, Kensuke
Sawada, Shunsuke
Baba, Kazuyasu
Yagi, Masao
Asako, Mikiya
Okazaki, Haruka
Ikeda, Hiroki
Kawamura, Shigeki
Nakamura, Akihiko
Dombrowicz, David
Tomoda, Koichi
Iwai, Hiroshi
|
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Eosinophilic chronic rhinosinusitis (ECRS) is a subtype of chronic rhinosinusitis associated with asthma. CD69 is an important marker of activation for eosinophils. But, whether a correlation exist between the CD69 expression on eosinophils and clinical findings is unclear. |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
We performed quantitative PCR and/or flow cytometry using tissue and purified eosinophils from the blood and nasal polyps of 12 patients with ECRS and from 8 patients without ECRS (controls). We assessed clinical findings including nasal polyp (NP) scores, sinus CT findings, and pulmonary function test results, and examined their possible association with the CD69 expression. We also performed CD69 cross-linking experiments in mouse eosinophils to investigate the functional role of CD69. |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Levels of cytokine mRNAs (IL-4, -5, -10, and -13) were significantly higher in purified NP eosinophils and tissues from patients with ECRS than the levels of those in controls. The expressions of major basic protein (MBP), eosinophilic cationic protein (ECP), eosinophilic-derived neurotoxin (EDN), eosinophil peroxidase (EPX) in cytotoxic granules, and CD69 mRNA were significantly higher in purified eosinophils from NPs than in those from blood. We also found a correlation between expression of CD69 and clinical findings. Moreover, we found EPX release from mouse eosinophils following CD69 cross-linking. |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
These data suggest that increased CD69 expression by eosinophils is not only a biomarker for nasal obstruction and pulmonary dysfunction, but also a potential therapeutic target for patients with ECRS and asthma. |
| 学位名 |
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学位名 |
博士（医学） |
| 学位授与機関 |
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学位授与機関名 |
関西医科大学 |
| 学位授与年度 |
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内容記述タイプ |
Other |
|
内容記述 |
令和元年度 |
| 学位授与年月日 |
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学位授与年月日 |
2020-03-24 |
| 学位授与番号 |
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学位授与番号 |
課博第1059号 |
| 書誌情報 |
Allergology international
en : Allergology international
巻 69,
号 2,
p. 232-238,
発行日 2020-04
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| DOI |
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10.1016/j.alit.2019.11.002 |
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https://doi.org/10.1016/j.alit.2019.11.002 |
論文要旨（要約） (123.0 kB)
