{"created":"2023-05-15T08:16:14.358629+00:00","id":76,"links":{},"metadata":{"_buckets":{"deposit":"fa5281d7-ae4b-4118-b685-a8f0c5bf304f"},"_deposit":{"created_by":6,"id":"76","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"76"},"status":"published"},"_oai":{"id":"oai:kmu.repo.nii.ac.jp:00000076","sets":["2:13:15:16"]},"author_link":["430","426","431","421","422","420","423","433","417","427","419","429","416","418","432","428","425","424"],"item_10006_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"（１型自己免疫性膵炎 では 細胞外小胞由来 microRNA 21 が高発現している ）"}]},"item_10006_biblio_info_23":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"324","bibliographicPageStart":"318","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"Pancreatology"},{"bibliographic_title":"Pancreatology","bibliographic_titleLang":"en"}]}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-24"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"関西医科大学"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"令和元年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The molecular basis of type 1 autoimmune pancreatitis (AIP) remains unclear. Recent attention on the role of extracellular vesicles microRNA (EV miRNA) in immune homeostasis has prompted us to perform an extensive miRNA screening of serum-derived EV in AIP.","subitem_description_type":"Abstract"},{"subitem_description":"EV miRNA expression was analyzed using microarrays in AIP, chronic pancreatitis (CP), and healthy adult (HC) samples (n = 10 from each group). Differences in signals, > 3 or <1/3 times, represented significant differences in expression. Another cohort of AIP (n = 14), CP (n = 10), and HC (n = 10) samples of EV miRNA was analyzed using reverse-transcription polymerase chain reaction (RT-PCR). miRNA expression in pancreatic tissues was evaluated using in situ hybridization (ISH) in three additional subjects from each group.","subitem_description_type":"Abstract"},{"subitem_description":"Signals of eight miRNAs (miR-659-3p, -27a-3p, -99a-5p, -21-5p, -205-5p, -100-5p, -29c-3p, and -125b-1-3p) were significantly higher, while those of two miRNAs (miR-4252 and -5004-5p) were significantly lower in AIP than in HC. EV miR-21-5p was significantly up-regulated in AIP than in HC (P = 0.035) and CP (P = 0.048). The number of miR-21-5p positive inflammatory cells was significantly elevated in AIP than in CP (P = 0.014).","subitem_description_type":"Abstract"},{"subitem_description":"Circulating EVs exhibited altered miRNA expression patterns with elevated miR-21-5p in AIP when compared with those in HC and CP. miR-21-5p was highly expressed in pancreatic inflammatory cells in AIP. Our data suggests that miR-21-5p may be involved in the regulation of effector pathways in the pathophysiology of AIP, thus differentiating AIP from CP.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"課博第1063号"}]},"item_10006_link_22":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_link_text":"10.1016/j.pan.2020.02.012","subitem_link_url":"https://doi.org/10.1016/j.pan.2020.02.012"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中丸, 洸"},{"creatorName":"ナカマル, コウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"416","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamaru, Koh","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"417","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomiyama, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"418","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Sanshiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"419","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikemune, Manami","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"420","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsukuda, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"421","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"422","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Toshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"423","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamaguchi, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"424","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ando, Yugo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"425","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikeura, Tsukasa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"426","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukui, Toshiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"427","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishio, Akiyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"428","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takaoka, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"429","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uchida, Kazushige","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"430","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Leung, Patrick S C","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"431","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Gershwin, M E","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"432","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okazaki, Kazuichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"433","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-18"}],"displaytype":"simple","filename":"甲1063 論文要旨（要約）.pdf","filesize":[{"value":"159.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"論文要旨（要約）","url":"https://kmu.repo.nii.ac.jp/record/76/files/甲1063 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microRNA-21.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"6","path":["16"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-08-18"},"publish_date":"2020-08-18","publish_status":"0","recid":"76","relation_version_is_last":true,"title":["Extracellular vesicles microRNA analysis in type 1 autoimmune pancreatitis: Increased expression of microRNA-21."],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T08:22:46.018197+00:00"}