| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2020-08-03 |
| タイトル |
|
|
タイトル |
Characteristics and clinical significance of augmentation spectra in solar urticaria. |
| タイトル |
|
|
タイトル |
Characteristics and clinical significance of augmentation spectra in solar urticaria. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_46ec |
|
資源タイプ |
thesis |
| 別タイトル |
|
|
その他のタイトル |
（日光蕁麻疹における増強波長の特徴と臨床的意義） |
| 著者 |
上津, 直子
Uetsu, Naoko
Nomura, Yuki
Matsuyama, Yoshie
Okamoto, Hiroyuki
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Solar urticaria has unique spectra, such as inhibition and augmentation. The clinical significance of these spectra, especially augmentation, is not well understood. Reported cases of solar urticaria with augmentation spectra are extremely rare in the published English-language work. The purposes of this study were to evaluate the clinical features of solar urticaria with augmentation spectra and to elucidate the mechanisms and clinical importance of the spectra. We experienced 11 cases (five females, six males; mean age, 40.1 years; range, 1-74) of solar urticaria with augmentation spectra from April 2007 to July 2019. Augmentation spectra were UV-B in three cases, UV-A in two, visible light in four, UV-A and UV-B in one, and UV-A and visible light in one. Augmentation spectra were observed before action spectra in four cases, after in six, and before and after in one. Injection of sera irradiated with action spectra and augmentation spectra in vitro induced stronger immediate reactions than those of only action spectrum-irradiated sera in four of five cases. The results of injection tests suggested that augmentation spectra enhance the production of urticaria-forming factor. Clinically, we observed severe urticarial reactions in four cases, including anaphylaxis in three and moderate urticarial reactions in three. These results suggest that augmentation spectra are not as rare as previously thought and that they are associated with the severity of solar urticaria. Therefore, phototesting for both augmentation and action spectra should be performed to provide appropriate guidance for patients with solar urticaria. |
| 学位名 |
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|
学位名 |
博士（医学） |
| 学位授与機関 |
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学位授与機関名 |
関西医科大学 |
| 学位授与年度 |
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内容記述タイプ |
Other |
|
内容記述 |
令和元年度 |
| 学位授与年月日 |
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|
学位授与年月日 |
2020-03-24 |
| 学位授与番号 |
|
|
学位授与番号 |
論博第736号 |
| 書誌情報 |
The Journal of dermatology
en : The Journal of dermatology
巻 47,
号 4,
p. 369-377,
発行日 2020-04
|
| DOI |
|
|
|
10.1111/1346-8138.15234 |
|
|
https://doi.org/10.1111/1346-8138.15234 |
論文要旨（要約） (171.5 kB)
