| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2021-10-18 |
| タイトル |
|
|
タイトル |
Analysis of HLA haplotype and clinical factors during hematopoietic stem cell transplantation. |
| タイトル |
|
|
タイトル |
Analysis of HLA haplotype and clinical factors during hematopoietic stem cell transplantation. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_46ec |
|
資源タイプ |
thesis |
| 別タイトル |
|
|
その他のタイトル |
造血幹細胞移植における HLA ハプロタイプと臨床関連因子の解析 |
| 著者 |
小西, 晶子
Konishi, Akiko
Abe, Misao
Yamaoka, Manabu
Satake, Atsushi
Ito, Tomoki
Nomura, Shosaku
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The human leukocyte antigen (HLA) haplotype of the recipient in hematopoietic stem cell transplantation (HSCT) is a key factor in its success or failure. We analyzed the relationship between HLA haplotype frequency and associated clinical factors in HSCT patients. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Patients who underwent allogeneic HSCT between 2000 and 2019 at our institution were enrolled in this study. The HSCT composition was 77 bone marrow transplantations (BMT), 38 peripheral blood stem cell transplantations (PBSCT), and 36 cord blood transplantations (CBT). Patients were classified into three groups according to their donor HLA haplotype frequency in the Japan Population: group A, top 1-10 haplotypes; group B, top 11-100 haplotypes; and group C, haplotype 101-. We then compared various items including clinical biomarkers with the HLA haplotype frequency. |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
A significant negative correlation was identified between older persons and length of survival. There are also significant correlations between survival and levels of immunoglobulin G, D-dimer, and C-reactive protein, as well as the platelet-large cell ratio before transplantation. A total of 96, 30, and 25 patients were classified into groups A, B, and C, respectively. The HSCT match rate was significantly higher in group A patients than in those of groups B and C. In contrast, the death rate, D-dimer level, and length of time for engraftment were significantly higher in group B and C patients than in those of group A. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
An assessment of transplant-related complications is important in improving the performance of HSCT. The present data suggest that a special therapeutic strategy is necessary for HSCT using low-frequency HLA haplotypes. |
| 学位名 |
|
|
学位名 |
博士（医学） |
| 学位授与機関 |
|
|
|
学位授与機関名 |
関西医科大学 |
| 学位授与年度 |
|
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内容記述タイプ |
Other |
|
内容記述 |
令和3年度 |
| 学位授与年月日 |
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学位授与年月日 |
2021-09-28 |
| 学位授与番号 |
|
|
学位授与番号 |
論博第745号 |
| 書誌情報 |
Transplant immunology
en : Transplant immunology
巻 66,
p. 101376,
発行日 2021
|
| DOI |
|
|
|
10.1016/j.trim.2021.101376 |
|
|
https://pubmed.ncbi.nlm.nih.gov/33610676/#:~:text=DOI%3A-,10.1016/j.trim.2021.101376,-Full%20text%20links |
論文要旨（要約） (119.7 kB)
