| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2020-11-12 |
| タイトル |
|
|
タイトル |
Interleukin-35 promotes the differentiation of regulatory T cells and suppresses Th2 response in IgG4-related type 1 autoimmune pancreatitis. |
|
言語 |
en |
| タイトル |
|
|
タイトル |
Interleukin-35 promotes the differentiation of regulatory T cells and suppresses Th2 response in IgG4-related type 1 autoimmune pancreatitis. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_46ec |
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資源タイプ |
thesis |
| 別タイトル |
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その他のタイトル |
( IL 35 は IgG4 関連 1 型自己免疫性膵炎の制御性 T 細胞の分化を誘導し 、 Th2 免疫 応答を抑制する) |
| 著者 |
伊藤, 嵩志
Ito, Takashi
Tanaka, Toshihiro
Nakamaru, Koh
Tomiyama, Takashi
Yamaguchi, Takashi
Ando, Yugo
Ikeura, Tsukasa
Fukui, Toshiro
Uchida, Kazushige
Nishio, Akiyoshi
Okazaki, Kazuichi
|
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
IgG4-related disease (IgG4-RD) is a systemic inflammatory disease, which includes type 1 autoimmune pancreatitis (AIP). Interleukin-35 (IL-35) exhibits immunosuppressive effects in several autoimmune diseases. However, the expression of IL-35 had not been reported so far in type 1 AIP. We evaluated the association between IL-35 and several cytokines, which mediate the function of Tregs in type 1 AIP. |
| 抄録 |
|
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内容記述タイプ |
Abstract |
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内容記述 |
Plasma was collected from patients with type 1 AIP, alcoholic chronic pancreatitis (ACP), and healthy controls (HC) and assayed for cytokine expression. Total mRNA separated from peripheral blood was isolated from naïve Tregs (nTregs) and effector Tregs (eTregs). EBI3 and IL-12p35 gene expressions were tested in these cells by quantitative PCR. In addition, expression of IL-35 subunits in the pancreatic tissues of patients with type 1 AIP and ACP was analyzed by immunohistochemistry. |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
IL-35 was significantly elevated in type 1 AIP (n = 32) plasma compared with ACP (n = 16) and HC (n = 22), but IL-27 was not. We also detected many cells expressing both EBI3 and IL-12p35 in type 1 AIP tissues. Moreover, in peripheral blood lymphocyte, the percentage of nTregs and eTregs of CD4 |
| 抄録 |
|
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内容記述タイプ |
Abstract |
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内容記述 |
T cells in patients with type 1 AIP (n = 14) compared with HC (n = 15) was significantly decreased and increased, respectively. There were no significant differences of gene expression in patients with type 1 AIP and HC. |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
This study identified elevated expression of plasma IL-35 and tissue IL-35 subunits in patients with type 1 AIP. This might lead to inflammation suppression via activated eTregs. IL-35 might be associated with this anti-inflammatory role, especially against the Th2 response through several cytokines and the differentiation of Tregs in type 1 AIP. |
| 学位名 |
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学位名 |
博士（医学） |
| 学位授与機関 |
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学位授与機関名 |
関西医科大学 |
| 学位授与年度 |
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内容記述タイプ |
Other |
|
内容記述 |
令和2年度 |
| 学位授与年月日 |
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学位授与年月日 |
2020-09-29 |
| 学位授与番号 |
|
|
学位授与番号 |
課博第1075号 |
| 書誌情報 |
Journal of gastroenterology
en : Journal of gastroenterology
巻 55,
号 8,
p. 789-799,
発行日 2020-08
|
| DOI |
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10.1007/s00535-020-01689-5 |
|
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https://doi.org/10.1007/s00535-020-01689-5 |
論文要旨（要約） (161.5 kB)
