{"created":"2023-05-15T08:16:18.267581+00:00","id":142,"links":{},"metadata":{"_buckets":{"deposit":"ae57ed34-7615-46ff-acc3-64447edf7227"},"_deposit":{"created_by":6,"id":"142","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"142"},"status":"published"},"_oai":{"id":"oai:kmu.repo.nii.ac.jp:00000142","sets":["2:13:26:29"]},"author_link":["1063","1060","1062","1057","1059","1058","1056","1055","1061"],"item_10006_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"TGF-β シグナルはヒト骨組織由来 CD271、SSEA4 共陽性間葉系幹細胞の 細胞老化を促進する"}]},"item_10006_biblio_info_23":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"932","bibliographicPageStart":"920","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Stem Cell Reports"},{"bibliographic_title":"Stem Cell Reports","bibliographic_titleLang":"en"}]}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-03-27"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"関西医科大学"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"平成29年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It is generally thought that the proliferative capacity and differentiation potential of somatic stem cells, including mesenchymal stromal/stem cells (MSCs) and hematopoietic stem cells, decline with age. We investigated the effects of aging on human bone-derived MSCs expressing CD271 and SSEA-4 (double-positive MSCs [DPMSCs]). The percentages of DPMSCs in bone tissue decreased significantly with age. The DPMSCs from elderly patients (old DPMSCs) showed cellular senescence, which was evidenced by low growth potential, high senescence-associated β-galactosidase activity, and elevated p16 and p21 CDK inhibitor levels. Moreover, old DPMSCs showed weak osteogenic differentiation potential and less hematopoiesis-supporting activity in comparison with young DPMSCs. Interestingly, the addition of transforming growth factor β2 (TGF-β2) induced cellular senescence in young DPMSCs. With the exception of the adipogenic differentiation potential, all of the aging phenomena observed in old DPMSCs were reversed by the addition of anti-TGF-β antibodies. These results suggest that, in part, old DPMSCs accelerate cellular senescence through TGF-β signaling.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"課博第1020号"}]},"item_10006_link_22":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_link_text":"10.1016/j.stemcr.2018.01.030","subitem_link_url":"https://doi.org/10.1016/j.stemcr.2018.01.030"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河村, 孟"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawamura, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakatsuka, Ryusuke","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuoka, Yoshikazu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sumide, Keisuke","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujioka, Tatsuya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Asano, Hiroaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iida, Hirokazu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sonoda, Yoshiaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-26"}],"displaytype":"simple","filename":"甲1020　論文要旨（要約）.pdf","filesize":[{"value":"258.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"論文要旨（要約）","url":"https://kmu.repo.nii.ac.jp/record/142/files/甲1020　論文要旨（要約）.pdf"},"version_id":"69c72a27-a279-46f1-a894-5de3ccc7c5aa"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-26"}],"displaytype":"simple","filename":"甲1020　審査結果要旨.pdf","filesize":[{"value":"73.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査結果要旨","url":"https://kmu.repo.nii.ac.jp/record/142/files/甲1020　審査結果要旨.pdf"},"version_id":"9bdb9f8f-0874-493c-b61f-73c441d90838"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-31"}],"displaytype":"simple","filename":"甲1020　主論文.pdf","filesize":[{"value":"10.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"主論文","url":"https://kmu.repo.nii.ac.jp/record/142/files/甲1020　主論文.pdf"},"version_id":"98920104-54c4-4e7b-b3d0-11c67d816e8c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"TGF-β Signaling Accelerates Senescence of Human Bone-Derived CD271 and SSEA-4 Double-Positive Mesenchymal Stromal Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"TGF-β Signaling Accelerates Senescence of Human Bone-Derived CD271 and SSEA-4 Double-Positive Mesenchymal Stromal Cells"},{"subitem_title":"TGF-β Signaling Accelerates Senescence of Human Bone-Derived CD271 and SSEA-4 Double-Positive Mesenchymal Stromal Cells","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"6","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-08-26"},"publish_date":"2020-08-26","publish_status":"0","recid":"142","relation_version_is_last":true,"title":["TGF-β Signaling Accelerates Senescence of Human Bone-Derived CD271 and SSEA-4 Double-Positive Mesenchymal Stromal Cells"],"weko_creator_id":"6","weko_shared_id":6},"updated":"2023-05-15T08:26:52.513667+00:00"}