{"created":"2023-05-15T08:16:18.044948+00:00","id":136,"links":{},"metadata":{"_buckets":{"deposit":"02a78258-a7af-4b7a-bd3e-75df63f17d63"},"_deposit":{"created_by":6,"id":"136","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"136"},"status":"published"},"_oai":{"id":"oai:kmu.repo.nii.ac.jp:00000136","sets":["2:13:26:29"]},"author_link":["1012","1014","1013","1011","1008","1010","1015","1035","1009","1007","1016"],"item_10006_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"局所再発胸部腫瘍に対する再照射についての単施設・後方視的検討"}]},"item_10006_biblio_info_23":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Radiation Oncology"},{"bibliographic_title":"Radiation Oncology","bibliographic_titleLang":"en"}]}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-03-27"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"関西医科大学"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"平成29年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nRe-irradiation (re-RT) of the thorax is challenging due to the impact of prior therapies on normal tissues, and there are few reports of definitive re-RT. The treatment toxicities and efficacy of re-RT are not well known. The aim of the present study was to assess the safety and efficacy of definitive re-RT of the thorax.\n\nMethods\nPatients who were treated with thoracic re-RT between March 2007 and December 2014 were retrospectively analyzed. Primary and re-irradiation plans were required to have an overlap of dose distributions for the 80 % isodose level. All doses were recalculated to an equivalent dose of 2 Gy per fraction (EQD2). When possible, analysis of dose accumulation was carried out using the medical image merge (MIM) (®) software program (version 6.5, MIM Software Inc., Cleveland, OH). Administration dosages for organs at risk were defined.\n\nResults\nFourteen (67 %) and seven (33 %) patients with non-small cell carcinoma (NSCLC) and small cell carcinoma (SCLC), respectively, were identified. The patients’ median age was 72 (range 53–85) years. Fifteen patients (71 %) had “proximal” tumors, defined as tumors at the distal 2 cm of the trachea, carina, and main bronchi. The median interval from initial RT to re-RT was 26.8 (range 11.4–92.3) months. Re-RT was delivered by X-ray beam and proton beam therapy in 20 (95 %) patients and 1 (5 %) patient, respectively. The median radiation dose of re-RT was 60 (range 54–87.5) Gy10 and 50 (range 50.0–87.5) Gy10 for patients with NSCLC and SCLC, respectively. Grade 3 acute radiation pneumonitis occurred in only one patient. There were no other serious complications. The median follow-up time was 22.1 (range 2.3–56.4) months. The median local progression-free survival time (LPFS) and overall survival time (OS) were 12.9 (95 % confidence interval (CI): 8.9–27.9) months and 31.4 (95 % CI: 16.9–45.9) months, respectively. Patients receiving ≥ 60 Gy10 at re-RT had longer LPFS (p = 0.04).\n\nConclusions\nGood safety with longer OS than in previous reports was demonstrated. Re-RT seems to be a promising treatment option. Further study to define the risk-benefit ratios is necessary.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"課博第1015号"}]},"item_10006_link_22":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_link_text":"10.1186/s13014-016-0673-z","subitem_link_url":"https://doi.org/10.1186/s13014-016-0673-z"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"角田, 貴代美"}],"nameIdentifiers":[{"nameIdentifier":"1035","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sumita, Kiyomi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1007","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Harada, Hideyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1008","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Asakura, Hirofumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1009","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, Hirofumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Onoe, Tsuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murayama, Shigeyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1012","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Satoaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1013","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanigawa, Noboru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Toshiaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1015","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Tetsuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1016","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-26"}],"displaytype":"simple","filename":"甲1015　論文要旨（要約）.pdf","filesize":[{"value":"139.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"論文要旨（要約）","url":"https://kmu.repo.nii.ac.jp/record/136/files/甲1015　論文要旨（要約）.pdf"},"version_id":"766442d1-6ab5-4c6d-b0b5-2463aae3ce20"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-26"}],"displaytype":"simple","filename":"甲1016　審査結果要旨.pdf","filesize":[{"value":"84.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査結果要旨","url":"https://kmu.repo.nii.ac.jp/record/136/files/甲1016　審査結果要旨.pdf"},"version_id":"bf162e1e-6dd3-4487-9d67-964f9f34d751"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-31"}],"displaytype":"simple","filename":"甲1015　主論文.pdf","filesize":[{"value":"687.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"主論文","url":"https://kmu.repo.nii.ac.jp/record/136/files/甲1015　主論文.pdf"},"version_id":"e5695bf5-1a17-49df-9693-8e6f90272fae"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Re-irradiation for locoregionally recurrent tumors of the thorax: a single-institution, retrospective study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Re-irradiation for locoregionally recurrent tumors of the thorax: a single-institution, retrospective study"},{"subitem_title":"Re-irradiation for locoregionally recurrent tumors of the thorax: a single-institution, retrospective study","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"6","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-08-26"},"publish_date":"2020-08-26","publish_status":"0","recid":"136","relation_version_is_last":true,"title":["Re-irradiation for locoregionally recurrent tumors of the thorax: a single-institution, retrospective study"],"weko_creator_id":"6","weko_shared_id":6},"updated":"2023-05-15T08:27:18.822692+00:00"}