| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2020-08-24 |
| タイトル |
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タイトル |
Morphological and immunohistochemical comparison of intrapancreatic nerves between chronic pancreatitis and type 1 autoimmune pancreatitis. |
| タイトル |
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タイトル |
Morphological and immunohistochemical comparison of intrapancreatic nerves between chronic pancreatitis and type 1 autoimmune pancreatitis. |
|
言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_46ec |
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資源タイプ |
thesis |
| 別タイトル |
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その他のタイトル |
（慢性膵炎と1型自己免疫性膵炎における膵内神経の形態学的および免疫組織化学的比較） |
| 著者 |
加藤, 孝太
Kato, Kota
Ikeura, Tsukasa
Yanagawa, Masato
Tomiyama, Takashi
Fukui, Toshiro
Uchida, Kazushige
Takaoka, Makoto
Nishio, Akiyoshi
Uemura, Yoshiko
Satoi, Sohei
Yamada, Hisao
Okazaki, Kazuichi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The abdominal pain associated with chronic pancreatitis (CP) may be related to the increased number and size of intrapancreatic nerves. On the other hand, patients with type 1 autoimmune pancreatitis (AIP) rarely suffer from the pain syndrome, and there are no previous studies concerning the histopathological findings of intrapancreatic nerves in patients with type 1 AIP. The current study is aimed at investigating the differences in the histopathological and immunohistochemical findings of intrapancreatic nerves in patients with CP and type 1 AIP. |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Neuroanatomical differences between CP and type 1 AIP were assessed by immunostaining with a pan-neuronal marker, protein gene product 9.5 (PGP9.5). The number (neural density) and area (neural hypertrophy) of PGP9.5-immunopositive nerves were quantitatively analyzed. Furthermore, the expression of nerve growth factor (NGF), and a high affinity receptor for NGF, tyrosine kinase receptor A (TrkA), was assessed by immunohistochemistry. |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Both neural density and hypertrophy were significantly greater in pancreatic tissue samples from patients with CP than those with normal pancreas or type 1 AIP. NGF expression was stronger in type 1 AIP than in CP, whereas TrkA expression in type 1 AIP was poorer than in CP. |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Although CP and type 1 AIP are both characterized by the presence of sustained pancreatic inflammation, they are different in terms of the density and hypertrophy of intrapancreatic nerve fibers. It is possible that this may be related to the difference in the activity of the NGF/TrkA-pathway between the two types of pancreatitis. |
| 学位名 |
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学位名 |
博士（医学） |
| 学位授与機関 |
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学位授与機関名 |
関西医科大学 |
| 学位授与年度 |
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内容記述タイプ |
Other |
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内容記述 |
平成29年度 |
| 学位授与年月日 |
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学位授与年月日 |
2017-09-26 |
| 学位授与番号 |
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学位授与番号 |
課博第1005号 |
| 書誌情報 |
Pancreatology
en : Pancreatology
巻 17,
号 3,
p. 403-410,
発行日 2017 May
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| DOI |
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10.1016/j.pan.2017.02.009 |
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https://doi.org/10.1016/j.pan.2017.02.009 |
論文要旨（要約） (202.8 kB)
