| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2020-08-24 |
| タイトル |
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タイトル |
A nuclear factor-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates GVHD in allogeneic bone marrow transplantation. |
| タイトル |
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タイトル |
A nuclear factor-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates GVHD in allogeneic bone marrow transplantation. |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_46ec |
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資源タイプ |
thesis |
| 別タイトル |
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その他のタイトル |
(移植片対宿主病に対する新規NF-κB阻害剤dehydroxymethylepoxyquinomicin（DHMEQ）の治療効果) |
| 著者 |
山内, 壮作
Yamanouchi, Sohsaku
Adachi, Yasushi
Shimo, Tomohiko
Umezawa, Kazuo
Okigaki, Mitsuhiko
Tsuji, Shoji
Li, Ming
Takaya, Junji
Kuge, Tomohiro
Ikehara, Susumu
Kaneko, Kazunari
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
GVHD is a crucial mortality factor in allogeneic bone marrow transplantation (ABMT). In this paper, we show that dehydroxymethylepoxyquinomicin (DHMEQ), a novel inhibitor of nuclear factor-κB, suppresses GVHD, resulting in an improved mortality rate in a mouse ABMT model. Bone marrow cells from C57BL/6 mice (B6 mice) were transplanted into lethally irradiated BALB/c mice. Two weeks later, spleen cells from B6 mice were transplanted into the irradiated BALB/c mice. From one week after the injection of spleen cells, when the mice started to show GVHD, the mice were also injected intraperitoneally daily with DHMEQ or vehicle only (DMSO) for 4 weeks. By 80 days after the ABMT, 6/14 of the vehicle-injected mice (43%) had died because of GVHD, whereas all DHMEQ-injected mice survived this observation period and developed milder GVHD than the vehicle-injected mice. When regulatory T cells were reduced by the injection of anti-folate receptor 4 (FR4) antibody, the effects of DHMEQ were reduced. These findings suggest that administration of DHMEQ could become a new strategy for preventing fatalities from GVHD. |
| 学位名 |
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学位名 |
博士（医学） |
| 学位授与機関 |
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学位授与機関名 |
関西医科大学 |
| 学位授与年度 |
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内容記述タイプ |
Other |
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内容記述 |
平成29年度 |
| 学位授与年月日 |
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学位授与年月日 |
2017-09-26 |
| 学位授与番号 |
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学位授与番号 |
課博第1003号 |
| 書誌情報 |
Immunobiology
en : Immunobiology
巻 220,
号 9,
p. 1059-1066,
発行日 2015-09
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| DOI |
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10.1016/j.imbio.2015.05.011 |
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https://doi.org/10.1016/j.imbio.2015.05.011 |
論文要旨（要約） (233.5 kB)
