| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2020-08-24 |
| タイトル |
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タイトル |
Urinary Biomarkers for Screening for Renal Scarring in Children with Febrile Urinary Tract Infection: Pilot Study. |
| タイトル |
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タイトル |
Urinary Biomarkers for Screening for Renal Scarring in Children with Febrile Urinary Tract Infection: Pilot Study. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_46ec |
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資源タイプ |
thesis |
| 別タイトル |
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その他のタイトル |
(小児の有熱性尿路感染症における腎瘢痕のスクリーニングのための尿中バイオマーカーについてのパイロットスタディー) |
| 著者 |
北尾, 哲也
Kitao, Tetsuya
Kimata, Takahisa
Yamanouchi, Sohsaku
Kato, Shogo
Tsuji, Shoji
Kaneko, Kazunari
|
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Recurrent febrile urinary tract infections during infancy cause renal scarring, which is characterized by progressive focal interstitial fibrosis and may lead to renal failure. Renal scarring can be diagnosed through scintigraphy, although it seems impractical to perform renal scintigraphy for all infants with febrile urinary tract infections. Therefore, it is important to search for a biomarker to identify the presence of renal scarring. We hypothesized that urinary biomarkers of nephropathy may increase in infants with renal scarring following febrile urinary tract infections. |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
A total of 49 infants who underwent renal scintigraphy for febrile urinary tract infections were enrolled in the study. Several measurements were performed using urine samples, including total proteins, beta2-microglobulins, N-acetyl-β-D-glucosaminidase, neutrophil gelatinase associated lipocalin, liver-type fatty acid binding protein and angiotensinogen. Values were corrected by creatinine and compared between patients with and without renal scarring. |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Among urinary biomarkers only angiotensinogen in patients with scarring (median 14.6 μg/gm creatinine) demonstrated significantly higher levels than in patients without scarring (3.6 μg/gm creatinine, p <0.001). |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Urinary angiotensinogen may be useful for diagnosing the presence of renal scarring. |
| 学位名 |
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学位名 |
博士（医学） |
| 学位授与機関 |
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学位授与機関名 |
関西医科大学 |
| 学位授与年度 |
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内容記述タイプ |
Other |
|
内容記述 |
平成29年度 |
| 学位授与年月日 |
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学位授与年月日 |
2017-09-26 |
| 学位授与番号 |
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学位授与番号 |
課博第1001号 |
| 書誌情報 |
The Journal of urology
en : The Journal of urology
巻 194,
号 3,
p. 766-771,
発行日 2015-09
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| DOI |
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10.1016/j.juro.2015.04.091 |
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https://doi.org/10.1016/j.juro.2015.04.091 |
論文要旨（要約） (157.9 kB)
